What kind of future innovations and development plans is AHT preparing
Hair multiplication is a procedure in which donor hair (extracted hair) or fragments (cut hair follicles) are implanted directly into the scalp (in vivo), in hope that it will regenerate. The concept behind hair multiplication, by using the extracted hairs, tells us that it is a simple, non-invasive method that produces new cells, with a prepared tray that can be used to introduce and align newly born cells in a new location. There is a hope that, during hair transplantation, in the stage of removal of a small part of the cells by extraction, sufficient tissue will be provided for the formation of new follicles, while the number of old ones will not decrease. The disadvantage of this method lies in the fact that extracting hair usually leads to the appearance of a hair that does not have enough cells to stimulate the generation of new follicles. At the global level, experiments with hair multiplication have been carried out, and there is evidence that a small portion of these cut hairs can eventually create new follicles, usually only one, which is thinner than it was originally. With this concept, in hair transplantation, we do not process implanted hair follicles, but we are transplanting together with untouched hair follicles, in anticipation that several of them will grow.
Hair cloning or genetic engineering of new hairs is a promising procedure, but it is still in the experimental phase. Scientists are able to isolate the germline or "stem cells" of the hair follicle, or even other cell types (e.g. the fibroblast at the root of the hair follicle), and differentiate them to the full growth of new follicles in the laboratory (in vitro). Under ideal conditions, this could lead to an infinite accumulation of donor hairs that would help in hair transplantation, and would be used to fill the thinning area while at the same time the donor area remains untouched. There are several promising reports from scientists from all over the world, primarily based on laboratory experiments on animals. But unfortunately there is no real evidence or scientific data that these treatments could be available to patients in the next few years. Cloning of the hairs remains a great hope for the future.
Scientists from all over the world are making efforts to isolate a larger number of genes responsible for various types of androgenetic alopecia in order to make this method of hair transplantation faster and more efficient. For now, we know that a certain number of genes play a role in the onset of androgenetic alopecia, such as age, pattern and evolution. A complete understanding of the genetic androgenetic alopecia can lead in the future to genetic testing that would establish the diagnosis of androgenetic alopecia during childhood, and thus it would be possible to carry out appropriate genetic treatment. The efforts are aimed at isolating the genes responsible for the androgenetic alopecia common in this population, as well as attempts to confirm a possible relationship between androgenetic alopecia, diet and environmental factors (e.g. smoking).
In connection with hair cloning, research is taking place around the world in the stem cells field and their role in the growth of hair. There are various reports claiming that, hypothetically, stem cells could be differentiated into different types of human cells, since they are primarily undifferentiated cells. There are a lot of stem cells in the fatty tissue, and there are speculations that the injection of fatty tissue isolated from the abdomen into the balding area will lead to the stimulation of unused hair follicles in the area, which could then cause new hair growth. According to recent reports, hair follicles that are in a state of rest in the balding area still contain a small number of stem cells, and if stimulated, they could give new hairs. Although stem cell research is interesting and promising, it is still at the level of experimentation and undetermined, so this alternative type of baldness treatment is not yet precisely defined as such.
Patients with androgenetic alopecia are advised to consult a specialist doctor before they try to test this insufficiently explained and scientifically unsupported treatment, as there is no scientific evidence that "fat tissue injections" or "stem cell" creams can have a satisfying effect on androgenetic alopecia. Our clinic follows the development in the field of stem cell research and hair transplantation with great care.
ACell’s Extracellular Matrix
ACell's Extracellular Matrix (ECM) is a natural biological material that can be implanted at the place of an injury or damaged tissue, in order to accelerate healing. The ECM is a complex mixture of proteins and glycosaminoglycans. Glycosaminoglycans (GAGs) are linear polysaccharides composed of two basic saccharides: an amino sugar and an uronic acid.
Graft stimulates the cells of the body to form new tissues specific to that place (this process is called "autocloning"). Therefore, instead of the organism producing scar tissue, the healing happens by restoration with new tissue, almost as if the injury did not occur. Studies conducted in the ECM area have shown that the tissues are remodeled very quickly by promoting neovascularization (the growth of new blood vessels) and employing mesenchymal cells that have been left without a “host“ (collagen releasing cells which have the ability to promote hair formation).
Research on hair transplantation
These effects result in faster wound healing, while scars, in hair transplantation, are less noticeable. The possibility of using biologically based matrices in the process of hair multiplication is real, but it takes a lot of work to make hair multiplication become a treatment with practical application in the treatment of baldness in men and women.
Our clinic is currently studying the use of the ECM option for multiplying hairs at the back of the head, as well as facilitating wound healing in hair transplantation interventions.